As the Cat, Greer Nelson is struck by a new Hydra weapon that will condemn her to death by radiation poisoning. To save her life, her mentor Dr.Tumolo takes her to the hidden lair of the Cat People to have her reborn as Tigra, the Were-Woman. Hydra attacks again, abducting Tigra, Tumolo, and the Cat People in an effort to gain the secret of their ultimate weapon. Jack Russell, the Werewolf, happens to be passing by when Tigra is taken and joins the fight. In order to defeat Hydra, Tumolo releases their final secret upon them, the same Black Plague that the Cat People had released and cured centuries ago.
